Screening Metabolomics of Extracellular Vesicles using the Xevo™ MRT Mass Spectrometer

A metabolomics study is designed to discover metabolic changes of any organism. The metabolome is very complex, containing 1000’s of compounds and identification of small molecule metabolites remains a significant challenge, with many analytes having similar molecular weights. Here we demonstrate the advantages of improved mass resolution and sub ppm mass accuracy offered by the Xevo MRT Mass Spectrometer (MS) for metabolomic studies. The benefits of this approach are demonstrated using a small feasibility metabolomics study aiming to construct a comparative metabolite profile for extracellular vesicles (EVs) and matrix bound vesicles (MBVs) obtained from MC3T3 pre osteoblasts under osteogenic culture conditions. In an aim to understand the two subtypes potentially varying roles in skeletal mineralization.

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Screening Metabolomics of Extracellular Vesicles using the Xevo™ MRT Mass Spectrometer

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