This application note presents the development and validation of a multiresidue method for the analysis of per- and polyfluoroalkyl substances (PFAS) in fruits, vegetables, and juices. The method uses QuEChERS extraction, followed by Enhanced Matrix Removal (EMR) mixed-mode passthrough cleanup using the Agilent Captiva EMR PFAS Food I cartridge, then LC/MS/MS detection. The method features simplified and efficient sample preparation, sensitive LC/MS/MS detection, and reliable quantitation using neat standard calibration curves. The method was demonstrated to meet the required limits of quantitation (LOQs), recovery, and repeatability for four core PFAS targets—perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluoronanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS)—and the remaining 26 PFAS targets in produce and juices.