Artificial Intelligence is transforming data center workloads, driving a shift to unprecedented rack power densities and complex infrastructure demands. The AI Disruption: Challenges and Guidance for Data Center Design explores how AI training clusters, inference servers, and rapidly advancing GPU technologies are reshaping power, cooling, rack, and management strategies. The paper outlines the physical and operational challenges—from voltage distribution and arc flash safety to liquid cooling adoption and advanced rack configurations—and offers practical guidance for both new builds and retrofits. With AI workloads projected to consume 15–20% of all data center energy by 2028, Schneider Electric’s experts provide actionable insights to help operators design resilient, efficient, and future-ready facilities capable of supporting the next generation of AI innovation.